HERC1 and PKM

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HERC1	PKM
Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	pyruvate kinase M1/2
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane	Extracellular Region Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Cilium Vesicle Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Pyruvate Kinase Complex Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity	Magnesium Ion Binding RNA Binding MRNA Binding Pyruvate Kinase Activity Protein Binding ATP Binding Kinase Activity MHC Class II Protein Complex Binding Potassium Ion Binding Identical Protein Binding ADP Binding Cadherin Binding Thyroid Hormone Binding
	Biological Process	Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Neuron Projection Development Regulation Of Catalytic Activity Neuromuscular Process Controlling Balance	Response To Hypoxia Liver Development Glycolytic Process ATP Biosynthetic Process Response To Nutrient Response To Gravity Programmed Cell Death Response To Muscle Inactivity Animal Organ Regeneration Cellular Response To Insulin Stimulus Pyruvate Biosynthetic Process Neutrophil Degranulation Skeletal Muscle Tissue Regeneration Canonical Glycolysis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Cytoplasmic Translation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs			Pyruvic acid L-Phospholactate 2-Phosphoglycolic Acid 6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one 1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine Copper Artenimol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		12 interacting genes: BAK1 EP300 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S	55 interacting genes: ANXA7 APP ARAF AURKB CCR4 CDC25A CDK4 CDKN1A CTNNB1 DLC1 DUX4 EGLN3 ENO3 EPM2A EXOSC5 FGFR1 GRB7 HERC1 HIF1A HULC KPNA1 LINC01554 LMO7 LNX1 MAPK1 MDM2 MYL2 MYOC NAGK NDRG1 NXT2 OLFM2 PAX8 PIN1 POLE2 PRKN PTEN RAF1 RAP1B RCC1 RELA RPP14 SHBG SMN1 SORBS2 SUMO1 SUMO2 TERF1 TINF2 TK1 TRIM35 TRIM55 TRIM63 UCHL5 YWHAQ
Entrez ID		8925	5315
HPRD ID		06894	01529
Ensembl ID		ENSG00000103657	ENSG00000067225
Uniprot IDs		A0A024R5W0 Q15751	A0A024R5Z9 B4DNK4 P14618 V9HWB8
PDB IDs		4O2W 4QT6	1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 4YJ5 5X0I 5X1V 5X1W 6B6U 6GG3 6GG4 6GG5 6GG6 6JFB 6NU1 6NU5 6NUB 6TTF 6TTH 6TTI 6TTQ 6V74 6V75 6V76 6WP3 6WP4 6WP5 6WP6
Enriched GO Terms of Interacting Partners?
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