HERC1

Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Neuron Projection Development Regulation Of Catalytic Activity Neuromuscular Process Controlling Balance
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		12 interacting genes: BAK1 EP300 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S
Entrez ID		8925
HPRD ID		06894
Ensembl ID		ENSG00000103657
Uniprot IDs		A0A024R5W0 Q15751
PDB IDs		4O2W 4QT6
Enriched GO Terms of Interacting Partners?
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