CCL22 and GCLC

Data Source:
BioGRID (two hybrid)

		CCL22	GCLC
Description		C-C motif chemokine ligand 22	glutamate-cysteine ligase catalytic subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Magnesium Ion Binding Glutamate-cysteine Ligase Activity Protein Binding ATP Binding Glutamate Binding ADP Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Response To Heat Response To Hormone Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Blood Vessel Diameter Maintenance
Pathways		Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs			Glutamic acid Cysteine
Diseases			Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Asthma ( 32296059) Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469)	Benign prostatic hyperplasia ( 30988330) Birth weight ( 31043758) Daytime sleep phenotypes ( 27126917) Monocyte percentage of white cells ( 32888494) Waist circumference ( 28552196)
Interacting Genes		10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1	1 interacting genes: CCL22
Entrez ID		6367	2729
HPRD ID		04263	06032
Ensembl ID		ENSG00000102962	ENSG00000001084
Uniprot IDs		O00626	E1CEI4 P48506 Q14TF0
PDB IDs
Enriched GO Terms of Interacting Partners?
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