EIF2B5 and STX11

Data Source:
BioGRID (two hybrid)

		EIF2B5	STX11
Description		eukaryotic translation initiation factor 2B subunit epsilon	syntaxin 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Golgi Apparatus Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane SNARE Complex Presynaptic Active Zone Membrane
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Response To Endoplasmic Reticulum Stress Myelination Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Intracellular Protein Transport Exocytosis Vesicle Fusion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494 27863252) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		12 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B STX11	97 interacting genes: APP AXIN1 AXIN2 BLOC1S6 BYSL C1orf109 CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNX3 SOGA1 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587
Entrez ID		8893	8676
HPRD ID		04898	09231
Ensembl ID		ENSG00000145191	ENSG00000135604
Uniprot IDs		Q13144	O75558
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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