EIF2B5

Description		eukaryotic translation initiation factor 2B subunit epsilon
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Response To Endoplasmic Reticulum Stress Myelination Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494 27863252) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B STX11
Entrez ID		8893
HPRD ID		04898
Ensembl ID		ENSG00000145191
Uniprot IDs		Q13144
PDB IDs		3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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