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STX11 and TBK1
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
STX11
TBK1
Description
syntaxin 11
TANK binding kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Plasma Membrane
Synaptic Vesicle
Endomembrane System
Integral Component Of Membrane
SNARE Complex
Presynaptic Active Zone Membrane
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
SNARE Binding
SNAP Receptor Activity
Protein Binding
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Vesicle Docking
Membrane Fusion
Activation Of Innate Immune Response
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Response To Virus
Viral Process
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Peptidyl-serine Phosphorylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Regulation Of Neuron Death
Positive Regulation Of Xenophagy
Pathways
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Potential therapeutics for SARS
Drugs
Fostamatinib
Diseases
Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS
Nicotine dependence symptom count (
25555482
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Amyotrophic lateral sclerosis (
29566793
27455348
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
97 interacting genes:
APP
AXIN1
AXIN2
BLOC1S6
BYSL
C1orf109
CARD9
CCBE1
CCDC120
CCDC125
CCDC184
CCDC196
CCDC33
CCHCR1
CCNK
CDCA7L
CDR2L
CRYBA4
CTBP2
CWF19L2
DISC1
DUSP29
EIF1AD
EIF2B5
FAM110A
FAM161A
FAM161B
FAM74A4
FAM90A1
FARS2
GOLGA8EP
GOLGA8F
HAUS1
HGS
HOXA1
IKBKG
IKZF3
KAT5
KCTD9
KDM1A
KIFC3
KLC3
KRT75
KXD1
LENG1
LONRF1
MAGOHB
MBD3L1
MBIP
MEOX2
MFAP1
MID2
MIS18A
NDC80
NTAQ1
PKN1
PPP1R18
PRKAB2
PRPF18
PRPF31
PSMA3
PSMC3
RAD51D
RNF6
RNF8
RNPS1
RUNX1T1
SCNM1
SH2D4A
SHC3
SIKE1
SLC38A2
SMARCE1
SNAP23
SNAP25
SNX3
SOGA1
STX1A
STX4
SUV39H1
TADA3
TAF6L
TBK1
TCEA2
TCF4
TLE5
TNFRSF21
TRIM41
TSGA10IP
UBASH3A
USHBP1
VAMP2
VPS52
ZCCHC10
ZNF19
ZNF417
ZNF587
44 interacting genes:
AGO2
APP
ATG9A
AZI2
CALCOCO2
CDC37
CDC42BPG
CYLD
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
MAP1LC3B
MAVS
MBP
MIB2
MTPAP
NCK1
NEDD4
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SIKE1
SMCR8
SMURF1
SQSTM1
STX11
TANK
TICAM1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TRIM27
TXLNG
XIAP
Entrez ID
8676
29110
HPRD ID
09231
05322
Ensembl ID
ENSG00000135604
ENSG00000183735
Uniprot IDs
O75558
Q9UHD2
PDB IDs
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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