KRIT1 and RGS4

Data Source:
BioGRID (pull down, unspecified method)

		KRIT1	RGS4
Description		KRIT1 ankyrin repeat containing	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Small GTPase Mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Cell Redox Homeostasis Regulation Of Catalytic Activity Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases		Cerebral cavernous malformation
GWAS		Coffee consumption ( 31046077) Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		7 interacting genes: FAS ITGB1BP1 PLCB3 RAP1A RGS4 TRPV4 UBE2K	13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		889	5999
HPRD ID		05020	03947
Ensembl ID		ENSG00000001631	ENSG00000117152
Uniprot IDs		A4D1F7 O00522	A0A024R909 P49798
PDB IDs		3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4
Enriched GO Terms of Interacting Partners?
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