RGS4 and COPB1

Data Source:
HPRD (in vivo, two hybrid)

		RGS4	COPB1
Description		regulator of G protein signaling 4	COPI coat complex subunit beta 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane COPI Vesicle Coat Transport Vesicle Secretory Granule Membrane Intracellular Membrane-bounded Organelle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Structural Molecule Activity Protein Binding
	Biological Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Viral Process Neutrophil Degranulation
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	HDL cholesterol ( 26780889) HDL cholesterol levels ( 32203549 28334899) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Vitamin D levels ( 25208829)
Interacting Genes		13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	44 interacting genes: ADAM19 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ SCYL1 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6
Entrez ID		5999	1315
HPRD ID		03947	02981
Ensembl ID		ENSG00000117152	ENSG00000129083
Uniprot IDs		A0A024R909 P49798	P53618
PDB IDs
Enriched GO Terms of Interacting Partners?
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