RGS4 and COPB2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RGS4	COPB2
Description		regulator of G protein signaling 4	COPI coat complex subunit beta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol COPI Vesicle Coat Transport Vesicle
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Structural Molecule Activity Protein Binding
	Biological Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Toxin Transport
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	Kawasaki disease ( 22446961) Male-pattern baldness ( 29146897)
Interacting Genes		13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	14 interacting genes: ARCN1 COPA COPE MCPH1 MFHAS1 NDRG1 NFKB1 PRKCE RGS2 RGS4 SACM1L SUMO2 TMED10 WBP2
Entrez ID		5999	9276
HPRD ID		03947	06103
Ensembl ID		ENSG00000117152	ENSG00000184432
Uniprot IDs		A0A024R909 P49798	P35606
PDB IDs
Enriched GO Terms of Interacting Partners?
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