DDX18 and CRMP1

Data Source:
HPRD (two hybrid)

		DDX18	CRMP1
Description		DEAD-box helicase 18	collapsin response mediator protein 1
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GO Annotations	Cellular Component	Chromosome Nucleolus Membrane	Nucleus Centrosome Spindle Cytosol Growth Cone Midbody Perikaryon
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	Dihydropyrimidinase Activity Protein Binding Filamin Binding Identical Protein Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cellular Response To Estradiol Stimulus	Microtubule Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance Negative Regulation Of Neuron Projection Development Negative Regulation Of Actin Filament Binding
Pathways			CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Neuritic plaque ( 31497858) Opioid overdose severity score ( 31362332) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels x loop diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Urate levels (BMI interaction) ( 25811787)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: APP CRMP1 MTA1 PATJ	80 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		8886	1400
HPRD ID		05894	03913
Ensembl ID		ENSG00000088205	ENSG00000072832
Uniprot IDs		Q8N254 Q9NVP1	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		3LY5	4B3Z
Enriched GO Terms of Interacting Partners?
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