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CAMK2A and CAMK2N2
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
CAMK2A
CAMK2N2
Description
calcium/calmodulin dependent protein kinase II alpha
calcium/calmodulin dependent protein kinase II inhibitor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Postsynaptic Density
Endocytic Vesicle Membrane
Neuron Projection
Dendritic Spine
Nucleoplasm
Centrosome
Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Calcium-dependent Protein Serine/threonine Kinase Activity
Kinase Activity
Glutamate Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Calcium-dependent Protein Kinase Inhibitor Activity
Protein Kinase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Response To Ischemia
Protein Phosphorylation
Calcium Ion Transport
Wnt Signaling Pathway, Calcium Modulating Pathway
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Peptidyl-serine Phosphorylation
Angiotensin-activated Signaling Pathway
Protein Autophosphorylation
Regulation Of Neurotransmitter Secretion
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Hydrolase Activity
Positive Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Dendritic Spine Development
Regulation Of Cellular Response To Heat
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Peptidyl-threonine Autophosphorylation
Regulation Of Endocannabinoid Signaling Pathway
Regulation Of Neuron Migration
Negative Regulation Of Protein Kinase Activity
Pathways
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Ca2+ pathway
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Hexatantalum Dodecabromide
1,4-Dithiothreitol
(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}
Fostamatinib
Diseases
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Inflammatory bowel disease (
28067908
)
Obesity-related traits (
23251661
)
Ulcerative colitis (
28067908
)
Major depressive disorder (
22472876
)
Interacting Genes
87 interacting genes:
ACTN1
ACTN2
ACTN4
ARID5A
ATF1
ATP2A2
C1orf94
CAMK2B
CAMK2D
CAMK2G
CAMK2N2
CDC37
CDK5R1
CDK5R2
CEBPB
CHAT
CREB1
DAPK2
DAZAP2
DLG1
EGFR
ETS1
FAM168A
FAM168B
GFAP
GLB1L2
GRIA1
GRIN1
GRIN2A
GRIN2B
HSF1
HYAL3
ITGA2B
ITGB1BP1
ITPKA
KRT18
KRT75
KRT76
KRTAP15-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP22-1
KRTAP23-1
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
LASP1
LENG8
LRRC7
MAPT
MPDZ
MRPL11
NOS1
NTAQ1
PDC
PPM1F
PSMC5
PTTG1
RALYL
RBFOX2
RBM47
RBPMS
RBPMS2
RCHY1
RHOXF2
RIMS1
SMAD2
SOX5
SQSTM1
SRF
SUOX
SYNGAP1
TAB2
TANC1
TCAF1
TEX37
TFAP2D
TIAL1
TRIM55
TRIM63
TSR2
TTC5
VARS1
YWHAB
ZBTB32
4 interacting genes:
ARHGAP32
CAMK2A
CAMK2B
LNX1
Entrez ID
815
94032
HPRD ID
06532
16377
Ensembl ID
ENSG00000070808
ENSG00000163888
Uniprot IDs
A8K161
Q7LDD5
Q8IWE0
Q9UQM7
Q96S95
PDB IDs
2VZ6
3SOA
5IG3
6OF8
6VZK
6W4O
6W4P
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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