DPM2 and PIGA

Data Source:
HPRD (in vitro)

		DPM2	PIGA
Description		dolichyl-phosphate mannosyltransferase subunit 2, regulatory	phosphatidylinositol glycan anchor biosynthesis class A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity	Protein Binding UDP-glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity	GPI Anchor Biosynthetic Process Positive Regulation Of Metabolic Process Preassembly Of GPI Anchor In ER Membrane Cellular Response To Leukemia Inhibitory Factor
Pathways		Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)	Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases			Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS		Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1	4 interacting genes: DPM2 PIGH PIGQ PIGY
Entrez ID		8818	5277
HPRD ID		16028	02410
Ensembl ID		ENSG00000136908	ENSG00000165195
Uniprot IDs		O94777	A0A2K4ZA02 P37287
PDB IDs
Enriched GO Terms of Interacting Partners?
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