PIGA and DPM2

Data Source:
HPRD (in vitro)

		PIGA	DPM2
Description		phosphatidylinositol glycan anchor biosynthesis class A	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding UDP-glycosyltransferase Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding Enzyme Activator Activity Enzyme Regulator Activity
	Biological Process	GPI Anchor Biosynthetic Process Positive Regulation Of Metabolic Process Preassembly Of GPI Anchor In ER Membrane Cellular Response To Leukemia Inhibitory Factor	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases		Paroxysmal nocturnal hemoglobinuria (PNH)
GWAS			Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		4 interacting genes: DPM2 PIGH PIGQ PIGY	7 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC SLC22A2 VKORC1
Entrez ID		5277	8818
HPRD ID		02410	16028
Ensembl ID		ENSG00000165195	ENSG00000136908
Uniprot IDs		A0A2K4ZA02 P37287	O94777
PDB IDs
Enriched GO Terms of Interacting Partners?
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