SUCLG2 and GPR143

Data Source:
HPRD (in vitro, in vivo)

		SUCLG2	GPR143
Description		succinate-CoA ligase GDP-forming subunit beta	G protein-coupled receptor 143
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Plasma Membrane Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming)	Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Melanosome Membrane Melanosome
	Molecular Function	Magnesium Ion Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding ATP Binding GTP Binding GDP Binding Protein-containing Complex Binding	G Protein-coupled Receptor Activity Protein Binding Dopamine Binding L-DOPA Receptor Activity L-DOPA Binding Tyrosine Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process	Eye Pigment Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Visual Perception Melanosome Localization Melanosome Transport Melanosome Organization Calcium-mediated Signaling Using Intracellular Calcium Source Phosphatidylinositol-mediated Signaling Regulation Of Calcium-mediated Signaling
Pathways		Citric acid cycle (TCA cycle)	Amine ligand-binding receptors G alpha (q) signalling events
Drugs		Phenethyl Isothiocyanate
Diseases			Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Congenital motor nystagmus (CMN); Idiopathic congenital nystagmus (ICN)
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 28552196) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320) Corneal astigmatism ( 22144915) Diabetic kidney disease ( 26305897) FEV1 ( 30804560) Height ( 20881960) Hip circumference ( 28552196) IgE levels ( 23146381) Lung function (FVC) ( 28166213 30804560) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Urinary metabolite levels in chronic kidney disease ( 31959995)	Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: GPR143 SGCG SUCLG1	2 interacting genes: GNAI1 SUCLG2
Entrez ID		8801	4935
HPRD ID		06799	02355
Ensembl ID		ENSG00000172340	ENSG00000101850
Uniprot IDs		Q96I99	P51810
PDB IDs		6WCV
Enriched GO Terms of Interacting Partners?
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