MADD and VPS13D

Data Source:
HPRD (two hybrid)

		MADD	VPS13D
Description		MAP kinase activating death domain	vacuolar protein sorting 13 homolog D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Synapse	Extrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting To Vacuole Mitochondrion Organization Protein Retention In Golgi Apparatus Positive Regulation Of Mitophagy
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)	Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ	1 interacting genes: MADD
Entrez ID		8567	55187
HPRD ID		04664	10593
Ensembl ID		ENSG00000110514	ENSG00000048707
Uniprot IDs		A0A0A0MRB5 Q8WXG6	Q5THJ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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