MPDZ and CLDN5

Data Source:
HPRD (in vivo)

		MPDZ	CLDN5
Description		multiple PDZ domain crumbs cell polarity complex component	claudin 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction
	Molecular Function	Protein Binding Protein C-terminus Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Viral Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly
Pathways			Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS		Central corneal thickness ( 32528159 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2	40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1
Entrez ID		8777	7122
HPRD ID		09155	03654
Ensembl ID		ENSG00000107186	ENSG00000184113
Uniprot IDs		O75970	D3DX19 O00501
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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