TNFSF12 and AGGF1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TNFSF12	AGGF1
Description		TNF superfamily member 12	angiogenic factor with G-patch and FHA domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity	Nucleic Acid Binding Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Angiogenesis
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Emotional recognition ( 31596458) HDL cholesterol levels ( 32203549) Myopia ( 27182965) Plateletcrit ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25	11 interacting genes: BLOC1S6 CCDC85B CHERP DHX15 FBXO28 IDH1 MAB21L3 MCRS1 SNRPC TNFSF12 TOE1
Entrez ID		8742	55109
HPRD ID		04074	07621
Ensembl ID		ENSG00000239697	ENSG00000164252
Uniprot IDs		O43508 Q4ACW9	Q8N302
PDB IDs		4HT1
Enriched GO Terms of Interacting Partners?
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