AGGF1 and TNFSF12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		AGGF1	TNFSF12
Description		angiogenic factor with G-patch and FHA domains 1	TNF superfamily member 12
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding Protein Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Angiogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BRAF and RAF fusions	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Emotional recognition ( 31596458) HDL cholesterol levels ( 32203549) Myopia ( 27182965) Plateletcrit ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: BLOC1S6 CCDC85B CHERP DHX15 FBXO28 IDH1 MAB21L3 MCRS1 SNRPC TNFSF12 TOE1	6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25
Entrez ID		55109	8742
HPRD ID		07621	04074
Ensembl ID		ENSG00000164252	ENSG00000239697
Uniprot IDs		Q8N302	O43508 Q4ACW9
PDB IDs			4HT1
Enriched GO Terms of Interacting Partners?
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