AGGF1 and IDH1

Data Source:
BioGRID (two hybrid)

		AGGF1	IDH1
Description		angiogenic factor with G-patch and FHA domains 1	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleic Acid Binding Protein Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Angiogenesis Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Positive Regulation Of Angiogenesis	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways		Signaling by BRAF and RAF fusions	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib
Diseases
GWAS			Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		11 interacting genes: BLOC1S6 CCDC85B CHERP DHX15 FBXO28 IDH1 MAB21L3 MCRS1 SNRPC TNFSF12 TOE1	16 interacting genes: AGGF1 CALM1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 LINC01554 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		55109	3417
HPRD ID		07621	00984
Ensembl ID		ENSG00000164252	ENSG00000138413
Uniprot IDs		Q8N302	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0
Enriched GO Terms of Interacting Partners?
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