LHFPL3 and TNFSF14

Data Source:
BioGRID (two hybrid)

		LHFPL3	TNFSF14
Description		LHFPL tetraspan subfamily member 3	TNF superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Sensory Perception Of Sound	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways			TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Autism spectrum disorder or schizophrenia ( 28540026) Diverticular disease ( 30177863) Educational attainment ( 23722424) Gout ( 22179738) Initial pursuit acceleration ( 29064472) Obesity ( 21552555) Regular attendance at a religious group ( 29970889) Response to lithium treatment in bipolar disorder ( 26806518) Social communication problems ( 24564958) Weight ( 28552196)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		3 interacting genes: PIGP RNF24 TNFSF14	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		375612	8740
HPRD ID		17273	05157
Ensembl ID		ENSG00000187416	ENSG00000125735
Uniprot IDs		A1L384 Q86UP9	O43557
PDB IDs			4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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