CRADD and DCXR

Data Source:
BioGRID (two hybrid)

		CRADD	DCXR
Description		CASP2 and RIPK1 domain containing adaptor with death domain	dicarbonyl and L-xylulose reductase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasmic Microtubule Plasma Membrane Microvillus Brush Border Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Identical Protein Binding L-xylulose Reductase (NAD+) Activity L-xylulose Reductase (NADP+) Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	Xylulose Metabolic Process Glucose Metabolic Process NADP Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate D-xylose Metabolic Process
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	Formation of xylulose-5-phosphate Essential pentosuria
Drugs			Dihydrogenphosphate Nicotinamide adenine dinucleotide phosphate
Diseases			Pentosuria
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494)	Refractive error ( 32231278)
Interacting Genes		22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1	3 interacting genes: APP CRADD GLRX2
Entrez ID		8738	51181
HPRD ID		04584	16320
Ensembl ID		ENSG00000169372	ENSG00000169738
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	A0A384NY14 Q7Z4W1
PDB IDs		2O71 2OF5 3CRD	1PR9 1WNT 3D3W
Enriched GO Terms of Interacting Partners?
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