CRADD and SLC35A3

Data Source:
BioGRID (two hybrid)

		CRADD	SLC35A3
Description		CASP2 and RIPK1 domain containing adaptor with death domain	solute carrier family 35 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Golgi Apparatus Integral Component Of Golgi Membrane
	Molecular Function	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding	UDP-galactose Transmembrane Transporter Activity UDP-N-acetylglucosamine Transmembrane Transporter Activity Protein Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway	UDP-N-acetylglucosamine Metabolic Process Carbohydrate Transport UDP-galactose Transmembrane Transport UDP-N-acetylglucosamine Transmembrane Transport
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) Transport of nucleotide sugars
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494)	Incident chronic kidney disease ( 30955190)
Interacting Genes		22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1	2 interacting genes: CRADD TP63
Entrez ID		8738	23443
HPRD ID		04584	10413
Ensembl ID		ENSG00000169372	ENSG00000117620
Uniprot IDs		B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43	A0A1W2PQL8 A0A1W2PRT7 A0A1W2PSD1 Q9Y2D2
PDB IDs		2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?
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