SNX3 and ARL6IP1

Data Source:
BioGRID (two hybrid)

		SNX3	ARL6IP1
Description		sorting nexin 3	ADP ribosylation factor like GTPase 6 interacting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Extracellular Exosome	Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Identical Protein Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Protein Deubiquitination Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways		WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		12 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RAB7A RPRM SCNN1A STX11 TSC22D2 USP10 VPS35	77 interacting genes: ACSF2 AQP6 ARL4D ARL6 C19orf18 CERT1 DIABLO EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GAS8 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MFSD14B MFSD5 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35C2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391
Entrez ID		8724	23204
HPRD ID		09333	09641
Ensembl ID		ENSG00000112335	ENSG00000170540
Uniprot IDs		O60493	A0A024QYV7 Q15041
PDB IDs		2MXC 2YPS 5F0J 5F0L 5F0M 5F0P
Enriched GO Terms of Interacting Partners?
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