MBTPS1 and C11orf58

Data Source:
BioGRID (two hybrid)

		MBTPS1	C11orf58
Description		membrane bound transcription factor peptidase, site 1	chromosome 11 open reading frame 58
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane	Cellular_component
	Molecular Function	Serine-type Endopeptidase Activity	Molecular_function
	Biological Process	Proteolysis Protein Import Into Nucleus Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Cholesterol Biosynthetic Process Regulation Of Vesicle-mediated Transport	Biological_process
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) CREB3 factors activate genes CREB3 factors activate genes Post-translational protein phosphorylation Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Iris color (a* coordinate) ( 30895295) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Lumbar spine bone mineral density ( 29499414) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8	16 interacting genes: A2M CEP126 EEF1G FBN3 MBTPS1 POLR2C PTN RNF19A RPLP1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP TRA2A ZBTB48
Entrez ID		8720	10944
HPRD ID		04522	18069
Ensembl ID		ENSG00000140943	ENSG00000110696
Uniprot IDs		Q14703	O00193
PDB IDs
Enriched GO Terms of Interacting Partners?
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