CBLB and SPRY2

Data Source:
HPRD (in vitro)

		CBLB	SPRY2
Description		Cbl proto-oncogene B	sprouty RTK signaling antagonist 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Membrane Raft	Nucleus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Microtubule End
	Molecular Function	Phosphotyrosine Residue Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Positive Regulation Of T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Peptidyl-amino Acid Modification Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction T Cell Activation Regulation Of GTPase Activity Regulation Of Protein Binding Positive Regulation Of Protein Catabolic Process Negative Regulation Of Alpha-beta T Cell Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Spry regulation of FGF signaling EGFR downregulation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 20453840 28445677) Waist circumference ( 31647587) Zinc levels ( 26025379)	Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Cleft lip with or without cleft palate ( 28054174) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734 28054174) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 22885922 24509480 30054458 20862305 29358691 30297969 26818947 31118516 32499647 30718926 28869590) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		54 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRK CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70	105 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		868	10253
HPRD ID		05136	03916
Ensembl ID		ENSG00000114423	ENSG00000136158
Uniprot IDs		B3KSS7 B4DYP3 B7ZAG1 Q13191	O43597
PDB IDs		2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI	3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?
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