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SPRY2 and LCE3E
Data Source:
BioGRID
(two hybrid)
SPRY2
LCE3E
Description
sprouty RTK signaling antagonist 2
late cornified envelope 3E
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Microtubule End
Molecular Function
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Protein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Angiogenesis
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of GTPase Activity
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Keratinization
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Formation of the cornified envelope
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Cleft lip with or without cleft palate (
28054174
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
28054174
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
22885922
24509480
30054458
20862305
29358691
30297969
26818947
31118516
32499647
30718926
28869590
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Common traits (Other) (
20585627
)
Inflammatory skin disease (
25574825
)
Plantar warts (
28928442
)
Psoriasis (
25854761
)
Interacting Genes
105 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
51 interacting genes:
ADAMTSL4
ALPP
CYSRT1
EFEMP2
GRN
GSC2
HOXA1
KPRP
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
MACO1
MDFI
NBPF19
NOTCH2NLA
NXF1
PLSCR2
RGS17
RGS20
SPRY2
SPRY3
TRIM42
VWC2
Entrez ID
10253
353145
HPRD ID
03916
13975
Ensembl ID
ENSG00000136158
ENSG00000185966
Uniprot IDs
O43597
Q5T5B0
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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