SPRY2 and ATRIP

Data Source:
BioGRID (two hybrid)

		SPRY2	ATRIP
Description		sprouty RTK signaling antagonist 2	ATR interacting protein
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Microtubule End	Nucleoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Spry regulation of FGF signaling EGFR downregulation	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Cleft lip with or without cleft palate ( 28054174) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734 28054174) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 22885922 24509480 30054458 20862305 29358691 30297969 26818947 31118516 32499647 30718926 28869590) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		105 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	22 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2 ZBTB14
Entrez ID		10253	84126
HPRD ID		03916
Ensembl ID		ENSG00000136158	ENSG00000164053
Uniprot IDs		O43597	A0A024R2U4 A0A024R307 Q8WXE1
PDB IDs		3BUM 3OB1 5HKY 5HKZ 5HL0	4IGK 4NB3 5YZ0
Enriched GO Terms of Interacting Partners?
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