JRK and TXK

Data Source:
BioGRID (two hybrid)

		JRK	TXK
Description		Jrk helix-turn-helix protein	TXK tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus Cytoplasm Ribonucleoprotein Complex	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	DNA Binding MRNA Binding Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Canonical Wnt Signaling Pathway	Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways			FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Urinary tract infection frequency ( 28928442)	Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)
Interacting Genes		36 interacting genes: ALAS1 BYSL C2CD6 CCDC136 CCDC57 CDC37 CNKSR3 FAM161A FBXO17 GOLGA6L9 HSF2BP IFRD2 KDM1A KPNA6 LDOC1 LGALS14 MTUS2 PDZD4 PICK1 PRICKLE1 TFIP11 TPM4 TRIM23 TRIM41 TRIP10 TSGA10 TXK USP2 UTP14C ZBTB8A ZNF343 ZNF417 ZNF620 ZNF629 ZNF655 ZRANB1	38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		8629	7294
HPRD ID		04442	02505
Ensembl ID		ENSG00000234616	ENSG00000074966
Uniprot IDs		O75564	P42681
PDB IDs			2DM0
Enriched GO Terms of Interacting Partners?
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