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TXK and TNS4
Data Source:
BioGRID
(two hybrid)
TXK
TNS4
Description
TXK tyrosine kinase
tensin 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Cytosol
Cytoskeleton
Focal Adhesion
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Actin Binding
Protein Binding
Biological Process
Cytokine Production
Adaptive Immune Response
Protein Phosphorylation
Activation Of Phospholipase C Activity
Integrin-mediated Signaling Pathway
Regulation Of Gene Expression
Regulation Of Platelet Activation
Positive Regulation Of Interferon-gamma Production
Peptidyl-tyrosine Autophosphorylation
Tissue Regeneration
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Apoptotic Process
Protein Localization
Pathways
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
MET interacts with TNS proteins
Drugs
Fostamatinib
Zanubrutinib
Diseases
GWAS
Crohn's disease (
23128233
)
Mean platelet volume (
32888494
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
32888494
27863252
)
Asthma (
31959851
)
Pancreatic cancer (
29422604
)
Pancreatic ductal adenocarcinoma (
30541042
)
Interacting Genes
38 interacting genes:
CBY2
CCDC33
CCR5
CLNK
CRK
CTLA4
DOK2
DUSP6
EFHC2
EGFR
ERBB2
ERBB3
ERBB4
FYN
GRB10
GRB2
HOMEZ
IKZF1
IKZF4
JRK
KIT
LCP2
MET
NCK2
NELFCD
PIK3R1
PRDM14
RBAK
SH2D2A
SOCS3
SOCS6
SRC
STAP2
TNS4
YTHDC1
ZNF587
ZNF792
ZNF835
25 interacting genes:
AR
CARD9
CBL
CYSRT1
EGFR
ERBB3
ERBB4
GAB1
GSTCD
HSF2BP
KAZN
KCTD4
MET
NME4
NR3C1
P4HA2
PIH1D1
PIK3R1
PPP3CA
RABEP1
RPAIN
TRIM21
TRIM27
TXK
ZRANB1
Entrez ID
7294
84951
HPRD ID
02505
12223
Ensembl ID
ENSG00000074966
ENSG00000131746
Uniprot IDs
P42681
Q6PJP3
Q8IZW8
PDB IDs
2DM0
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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