TXK and SH2D2A

Data Source:
HPRD (two hybrid)

		TXK	SH2D2A
Description		TXK tyrosine kinase	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding SH3 Domain Binding
	Biological Process	Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Angiogenesis Signal Transduction Cell Population Proliferation Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	VEGFA-VEGFR2 Pathway
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)	Autoimmune thyroid disease ( 32581359) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835	34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
Entrez ID		7294	9047
HPRD ID		02505	05152
Ensembl ID		ENSG00000074966	ENSG00000027869
Uniprot IDs		P42681	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2DM0
Enriched GO Terms of Interacting Partners?
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