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KHSRP and EXOSC3
Data Source:
HPRD
(in vitro, in vivo)
KHSRP
EXOSC3
Description
KH-type splicing regulatory protein
exosome component 3
Image
GO Annotations
Cellular Component
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
RNA Splicing, Via Transesterification Reactions
Regulation Of Transcription, DNA-templated
MRNA Processing
RNA Splicing
Regulation Of Gene Expression
MiRNA Metabolic Process
Negative Regulation Of Low-density Lipoprotein Particle Clearance
Regulation Of MRNA Stability
Negative Regulation Of Nitric Oxide Biosynthetic Process
MRNA Transport
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Cellular Response To Cytokine Stimulus
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Isotype Switching
Positive Regulation Of Isotype Switching
CUT Catabolic Process
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription
Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
KSRP (KHSRP) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Resveratrol
Artenimol
Diseases
GWAS
Interacting Genes
14 interacting genes:
A1CF
APBB1
BACE1
EXOSC2
EXOSC3
GADD45A
GSK3B
HNRNPA1
HNRNPH1
KLHL12
PARN
PTBP2
STK3
UBE2I
9 interacting genes:
APP
ATP5F1D
CDK5RAP1
EXOSC4
EXOSC5
EXOSC9
KHSRP
MPHOSPH6
TSR2
Entrez ID
8570
51010
HPRD ID
10350
16220
Ensembl ID
ENSG00000088247
ENSG00000107371
Uniprot IDs
Q92945
Q9NQT5
Q9NYS3
PDB IDs
2HH2
2HH3
2JVZ
2OPU
2OPV
4B8T
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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