KHSRP and PARN

Data Source:
HPRD (in vivo, in vitro)

		KHSRP	PARN
Description		KH-type splicing regulatory protein	poly(A)-specific ribonuclease
Image
GO Annotations	Cellular Component	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding	3'-5'-exoribonuclease Activity RNA Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Gene Expression MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA RNA 3'-end Processing Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Positive Regulation Of Telomerase Activity Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Telomerase RNA Stabilization NcRNA Deadenylation Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA	ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs		Resveratrol Artenimol
Diseases
GWAS			Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		14 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I	6 interacting genes: KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2
Entrez ID		8570	5073
HPRD ID		10350	07250
Ensembl ID		ENSG00000088247	ENSG00000140694
Uniprot IDs		Q92945	A0A494C0Q2 A0A494C1K5 B3KN69 O95453
PDB IDs		2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T	2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?
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