CBX4 and SATB1

Data Source:
BioGRID (two hybrid, two hybrid)

		CBX4	SATB1
Description		chromobox 4	SATB homeobox 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding SUMO Transferase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Phosphoprotein Binding SUMO Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Viral Process
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)	Adventurousness ( 30643258) Chronic mucus hypersecretion ( 24714607) Familial lung adenocarcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Itch intensity from mosquito bite ( 28199695) Left-handedness ( 32989287) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 22139419) Response to fenofibrate (HDL cholesterol levels) ( 27002377) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		23 interacting genes: ARID3C CBS CREBBP CSNK2B CTBP1 CTBP2 FHL1 H3-4 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP SUV39H1 TRIM21 UBE2I ZEB2	23 interacting genes: BAZ1A CASP6 CBX4 CHD3 CUX1 EP300 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5
Entrez ID		8535	6304
HPRD ID		04357	03647
Ensembl ID		ENSG00000141582	ENSG00000182568
Uniprot IDs		A0A0S2Z5B2 O00257	A0A024R2H1 Q01826
PDB IDs		2K28 3I8Z 5EPL	1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF
Enriched GO Terms of Interacting Partners?
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