SATB1 and TOPORS

Data Source:
BioGRID (two hybrid, two hybrid)

		SATB1	TOPORS
Description		SATB homeobox 1	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Protein Binding Sequence-specific DNA Binding	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Viral Process	Protein Polyubiquitination Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination
Pathways		Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins	SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Adventurousness ( 30643258) Chronic mucus hypersecretion ( 24714607) Familial lung adenocarcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Itch intensity from mosquito bite ( 28199695) Left-handedness ( 32989287) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 22139419) Response to fenofibrate (HDL cholesterol levels) ( 27002377) SjÃ¶gren's syndrome ( 24097067)	Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: BAZ1A CASP6 CBX4 CHD3 CUX1 EP300 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5	28 interacting genes: CASP8 CREBBP EPM2A H2AX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1
Entrez ID		6304	10210
HPRD ID		03647	11642
Ensembl ID		ENSG00000182568	ENSG00000197579
Uniprot IDs		A0A024R2H1 Q01826	Q9NS56
PDB IDs		1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF
Enriched GO Terms of Interacting Partners?
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