CBX4 and ZEB2

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		CBX4	ZEB2
Description		chromobox 4	zinc finger E-box binding homeobox 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding SUMO Transferase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Phosphoprotein Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Phosphatase Regulator Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Anatomical Structure Development Regulation Of Catalytic Activity Melanocyte Migration Regulation Of Melanosome Organization
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			Mowat-Wilson syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)	Adult body size ( 32376654) Adventurousness ( 30643258) Age-related nuclear cataracts ( 33311586) Childhood absence epilepsy ( 30531953) Chin dimples ( 27182965) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 30306274) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 22949513) Hand grip strength ( 29691431) High myopia ( 31816047) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965 30899065) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 23184150 25826619) Retinal detachment or retinal break ( 31816047) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 29483656 23974872) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Interacting Genes		23 interacting genes: ARID3C CBS CREBBP CSNK2B CTBP1 CTBP2 FHL1 H3-4 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP SUV39H1 TRIM21 UBE2I ZEB2	11 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I
Entrez ID		8535	9839
HPRD ID		04357	05780
Ensembl ID		ENSG00000141582	ENSG00000169554
Uniprot IDs		A0A0S2Z5B2 O00257	O60315
PDB IDs		2K28 3I8Z 5EPL	2DA7
Enriched GO Terms of Interacting Partners?
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