PKP4 and DSP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		PKP4	DSP
Description		plakophilin 4	desmoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cornified Envelope Nucleus Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Junction Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Cadherin Binding	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Cell-cell Junction Assembly Cell-cell Signaling Regulation Of Cell Adhesion Keratinization Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Cornification Cell-cell Adhesion	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Artenimol Zinc acetate
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)	Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 31710517 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		19 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B	31 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 CSTA DES DSC1 ENO3 EVPL IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM
Entrez ID		8502	1832
HPRD ID		05043	00513
Ensembl ID		ENSG00000144283	ENSG00000096696
Uniprot IDs		Q99569	B4DKX6 P15924 Q4LE79
PDB IDs			1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?
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