PIGY and ABCB4

Data Source:
BioGRID (two hybrid)

		PIGY	ABCB4
Description		phosphatidylinositol glycan anchor biosynthesis class Y	ATP binding cassette subfamily B member 4
Image		No pdb structure
GO Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity
	Biological Process	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		Synthesis of glycosylphosphatidylinositol (GPI)	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1
Drugs
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Bipolar disorder ( 22925353) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 30275531)
Interacting Genes		5 interacting genes: ABCB4 ERG28 FBXO7 PIGA TMEM72	3 interacting genes: HAX1 PIGY TESK1
Entrez ID		84992	5244
HPRD ID		17492	01371
Ensembl ID		ENSG00000255072	ENSG00000005471
Uniprot IDs		Q3MUY2	P21439
PDB IDs			6S7P
Enriched GO Terms of Interacting Partners?
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