ABCB4 and TESK1

Data Source:
BioGRID (two hybrid)

		ABCB4	TESK1
Description		ATP binding cassette subfamily B member 4	testis associated actin remodelling kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine Floppase Activity Phosphatidylethanolamine Flippase Activity Ceramide Floppase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport	Positive Regulation Of Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Negative Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes PFIC3, ICP3 and GBD1	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs			Fostamatinib
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Total cholesterol levels ( 30275531)
Interacting Genes		3 interacting genes: HAX1 PIGY TESK1	7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1
Entrez ID		5244	7016
HPRD ID		01371	03470
Ensembl ID		ENSG00000005471	ENSG00000107140
Uniprot IDs		P21439	Q15569 Q8NFJ4
PDB IDs		6S7P
Enriched GO Terms of Interacting Partners?
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