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ZC3H10 and PICALM
Data Source:
BioGRID
(two hybrid)
ZC3H10
PICALM
Description
zinc finger CCCH-type containing 10
phosphatidylinositol binding clathrin assembly protein
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Nucleus
Early Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Clathrin-coated Pit
Synaptic Vesicle
Cell Surface
Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Intrinsic Component Of Membrane
Vesicle
Presynaptic Membrane
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Postsynaptic Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Endosome To Plasma Membrane Transport Vesicle
Neurofibrillary Tangle
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Molecular Function
RNA Binding
Protein Binding
MiRNA Binding
Metal Ion Binding
SNARE Binding
Amyloid-beta Binding
Protein Binding
1-phosphatidylinositol Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Clathrin Binding
Small GTPase Binding
Clathrin Heavy Chain Binding
Cadherin Binding
Tau Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Posttranscriptional Regulation Of Gene Expression
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Endocytosis
Receptor-mediated Endocytosis
Vesicle Budding From Membrane
Axonogenesis
Learning Or Memory
Negative Regulation Of Gene Expression
Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane
Synaptic Vesicle Maturation
Vesicle-mediated Transport
Endosomal Transport
Hemopoiesis
Regulation Of Endocytosis
Receptor Internalization
Regulation Of Protein Localization
Vesicle Cargo Loading
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor-mediated Endocytosis
Clathrin Coat Assembly
Dendrite Morphogenesis
Iron Ion Homeostasis
Membrane Organization
Protein-containing Complex Assembly
Clathrin-dependent Endocytosis
Modulation Of Age-related Behavioral Decline
Regulation Of Vesicle Size
Membrane Bending
Amyloid-beta Clearance By Transcytosis
Positive Regulation Of Neuron Death
Regulation Of Amyloid-beta Formation
Positive Regulation Of Amyloid-beta Formation
Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Clathrin-coated Pit Assembly
Negative Regulation Of Protein Localization To Cell Surface
Pathways
Golgi Associated Vesicle Biogenesis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Anorexia nervosa (
28494655
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Alzheimer's disease (
22832961
19734902
21627779
31473137
)
Alzheimer's disease (late onset) (
21460841
30617256
24162737
)
Alzheimer's disease (onset between ages 58 and 79) (
30979435
)
Alzheimer's disease in APOE e4+ carriers (
25778476
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Chronic obstructive pulmonary disease (
30804561
)
Family history of Alzheimer's disease (
30617256
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) (
26741287
)
Mean platelet volume (
32888494
)
Platelet count (
32888494
27863252
)
Refractive error (
32231278
)
Tourette syndrome (
22889924
)
Interacting Genes
46 interacting genes:
AOC1
APPBP2
ARID5A
ATXN1
BOLL
C10orf55
C19orf54
CRX
DAB1
DAZAP2
FAM168B
FOSB
FOXH1
HIVEP1
INTS11
KLHDC7B
KRTAP19-1
KRTAP6-1
KRTAP6-2
KRTAP8-1
LASP1
MIR143
MSX2
NCS1
NFYA
OTX2
OXER1
PIAS2
PICALM
PLA2G10
POU2F1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RBM38
RBPMS
RBPMS2
RNF4
STAM2
TENT5A
TENT5B
TEX37
UBE2I
ZNF34
19 interacting genes:
AP2A1
ATXN1
ATXN1L
CASP3
CASP8
CDC42
CLTC
CLTCL1
CRX
DDIT3
EHD2
FCHO1
ITSN1
PELI2
PLCG1
RBPMS
SMURF1
TENM1
ZC3H10
Entrez ID
84872
8301
HPRD ID
07860
04320
Ensembl ID
ENSG00000135482
ENSG00000073921
Uniprot IDs
Q96K80
A0A024R5L7
A0A024R5P1
Q13492
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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