DPY30 and BEND3

Data Source:
BioGRID (two hybrid)

		DPY30	BEND3
Description		dpy-30 histone methyltransferase complex regulatory subunit	BEN domain containing 3
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Heterochromatin Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	RDNA Binding Protein Binding
	Biological Process	Chromatin Silencing At Telomere Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly DNA Methylation Histone H4-K20 Trimethylation Histone H3-K9 Trimethylation Histone H4 Acetylation Protein Homooligomerization Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation Positive Regulation Of ATP Metabolic Process
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Brain morphology (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (combined parental age at death) ( 29227965) Postprandial triglyceride response to high fat diet meal ( 26256467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	5 interacting genes: DPY30 FAM161A MCRS1 MORN4 UBTFL1
Entrez ID		84661	57673
HPRD ID		17434	18934
Ensembl ID		ENSG00000162961	ENSG00000178409
Uniprot IDs		B4DIS3 Q9C005	Q5T5X7
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV	5JNO
Enriched GO Terms of Interacting Partners?
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