BEND3 and DPY30

Data Source:
BioGRID (two hybrid)

		BEND3	DPY30
Description		BEN domain containing 3	dpy-30 histone methyltransferase complex regulatory subunit
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GO Annotations	Cellular Component	Heterochromatin Nucleoplasm Nucleolus	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	RDNA Binding Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly DNA Methylation Histone H4-K20 Trimethylation Histone H3-K9 Trimethylation Histone H4 Acetylation Protein Homooligomerization Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation Positive Regulation Of ATP Metabolic Process	Chromatin Silencing At Telomere Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (combined parental age at death) ( 29227965) Postprandial triglyceride response to high fat diet meal ( 26256467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969)	Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		5 interacting genes: DPY30 FAM161A MCRS1 MORN4 UBTFL1	33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19
Entrez ID		57673	84661
HPRD ID		18934	17434
Ensembl ID		ENSG00000178409	ENSG00000162961
Uniprot IDs		Q5T5X7	B4DIS3 Q9C005
PDB IDs		5JNO	3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
Enriched GO Terms of Interacting Partners?
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