DPY30 and CREB3L3

Data Source:
BioGRID (two hybrid)

		DPY30	CREB3L3
Description		dpy-30 histone methyltransferase complex regulatory subunit	cAMP responsive element binding protein 3 like 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	Golgi Membrane Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding CAMP Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing At Telomere Endosomal Transport Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation	Positive Regulation Of Acute Inflammatory Response Regulation Of Transcription By RNA Polymerase II Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Apolipoprotein A1 levels ( 32203549) Triglyceride levels ( 32203549)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	30 interacting genes: ATF6 BAD CEBPG CEP19 CREB3 CREB3L1 CSNK2A1 CYB561A3 DPY30 FATE1 GPR25 GSK3B KHDRBS1 KPNA2 MCRS1 MS4A13 PELI2 RHAG RIOK3 RUSF1 SGTA SGTB SLC38A7 SLC39A9 STX5 TCEANC TMEM239 TRAF3IP3 USP7 YIPF6
Entrez ID		84661	84699
HPRD ID		17434	16752
Ensembl ID		ENSG00000162961	ENSG00000060566
Uniprot IDs		B4DIS3 Q9C005	Q68CJ9
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
Enriched GO Terms of Interacting Partners?
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