TTBK1 and MAP2

Data Source:
HPRD (in vitro)

		TTBK1	MAP2
Description		tau tubulin kinase 1	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Dendrite Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tau Protein Binding
	Biological Process	Protein Phosphorylation Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation Positive Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of Cellular Protein Localization Negative Regulation Of Microtubule Binding Negative Regulation Of Microtubule Motor Activity
Pathways
Drugs			Estramustine Paclitaxel Docetaxel
Diseases
GWAS		Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 29403010 28739976)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 31504236 30980028) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) Left-handedness ( 32989287) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB	25 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A
Entrez ID		84630	4133
HPRD ID		11653	01140
Ensembl ID		ENSG00000146216	ENSG00000078018
Uniprot IDs		Q5TCY1	A0A024R3Y8 A0A024R3Z1 A0A024R409 P11137 Q6NYC5
PDB IDs		4BTJ 4BTK 4BTM 4NFM 4NFN
Enriched GO Terms of Interacting Partners?
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