TTBK1 and TUBB

Data Source:
HPRD (in vitro)

		TTBK1	TUBB
Description		tau tubulin kinase 1	tubulin beta class I
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Astrocyte Activation Positive Regulation Of Microglial Cell Activation Positive Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Synapse Organization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body size at age 10 ( 32376654) Diastolic blood pressure ( 29403010) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hemoglobin ( 32888494) Mean arterial pressure ( 29403010) Pulse pressure ( 28739976) Red blood cell count ( 32888494) Systolic blood pressure ( 26390057 29403010 28739976)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287)
Interacting Genes		5 interacting genes: CDK5R1 CSN1S1 MAP2 MAPT TUBB	73 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DUX4 DYNLL1 ESR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		84630	203068
HPRD ID		11653	01852
Ensembl ID		ENSG00000146216	ENSG00000196230
Uniprot IDs		Q5TCY1	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs		4BTJ 4BTK 4BTM 4NFM 4NFN	3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ
Enriched GO Terms of Interacting Partners?
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