CUL4B and DNMT3B

Data Source:
BioGRID (pull down)

		CUL4B	DNMT3B
Description		cullin 4B	DNA methyltransferase 3 beta
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm
	Molecular Function	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision Histone H2A Monoubiquitination Ribosome Biogenesis DNA Damage Response, Detection Of DNA Damage Post-translational Protein Modification Global Genome Nucleotide-excision Repair UV-damage Excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs			Decitabine
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)	Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS			Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		25 interacting genes: AHR APP AR CAND1 COMMD1 DCUN1D4 DDB1 DDB2 DNMT3B ESR1 HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PRDX3 PTEN RBX1 RNF7 SALL2 SIN3A TBL3 UBC UBE2D3 ZMAT4	38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		8450	1789
HPRD ID		02251	04209
Ensembl ID		ENSG00000158290	ENSG00000088305
Uniprot IDs		K4DI93 Q13620	Q9UBC3
PDB IDs		2DO7 4A0C 4A0L 4A64	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91
Enriched GO Terms of Interacting Partners?
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