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DNMT3B
Description
DNA methyltransferase 3 beta
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Molecular Function
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
DNA-methyltransferase Activity
Histone Deacetylase Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
DNA Methylation
Response To Toxic Substance
Response To Ionizing Radiation
Positive Regulation Of Gene Expression
Response To Activity
Response To Caffeine
Response To Estradiol
Response To Vitamin A
Response To Cocaine
Response To Drug
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Cellular Response To Hyperoxia
Cellular Response To Dexamethasone Stimulus
C-5 Methylation Of Cytosine
Pathways
PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
SUMOylation of DNA methylation proteins
DNA methylation
Drugs
Decitabine
Diseases
Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS
Brain morphology (MOSTest) (
32665545
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Inflammatory bowel disease (
23128233
)
Iron status biomarkers (iron levels) (
28334935
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Nicotine dependence (
28972577
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Prostate cancer (
29892016
)
Pulse pressure (
27841878
30578418
)
Total cholesterol levels (
30275531
)
Interacting Genes
38 interacting genes:
BAZ2A
CBX1
CBX3
CBX5
CMTM6
CUL4B
DDB1
DNMT1
DNMT3A
DNMT3L
DUSP23
EED
EZH2
H3C1
HDAC1
HDAC2
HELLS
KIF4A
MAP1LC3B
MBD4
NCAPG
NEDD8
NRIP1
PAM16
PCYT2
PLEKHJ1
RPS10
SMARCA5
SMC2
SPI1
SUMO1
SUV39H1
TDG
TSC22D1
UBE2I
UBE2W
WARS1
ZBTB18
Entrez ID
1789
HPRD ID
04209
Ensembl ID
ENSG00000088305
Uniprot IDs
Q9UBC3
PDB IDs
3FLG
3QKJ
5CIU
5NR3
5NRR
5NRS
5NRV
5NV0
5NV2
5NV7
5NVO
6KDA
6KDB
6KDL
6KDP
6KDT
6PA7
6R3E
6U8P
6U8V
6U8W
6U8X
6U90
6U91
Enriched GO Terms of Interacting Partners
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