DNMT3B and HELLS

Data Source:
BioGRID (pull down)

		DNMT3B	HELLS
Description		DNA methyltransferase 3 beta	helicase, lymphoid specific
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin
	Molecular Function	DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding	Chromatin Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia DNA Methylation Response To Toxic Substance Response To Ionizing Radiation Positive Regulation Of Gene Expression Response To Activity Response To Caffeine Response To Estradiol Response To Vitamin A Response To Cocaine Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus C-5 Methylation Of Cytosine	DNA Methylation DNA Methylation-dependent Heterochromatin Assembly Cell Cycle Multicellular Organism Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation
Drugs		Decitabine
Diseases		Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS		Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)	Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		38 interacting genes: BAZ2A CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18	9 interacting genes: - APP DNMT1 DNMT3B E2F3 GTSF1L HDAC1 MEOX2 SERTAD2
Entrez ID		1789	3070
HPRD ID		04209	07232
Ensembl ID		ENSG00000088305	ENSG00000119969
Uniprot IDs		Q9UBC3	A0A087WSW7 A0A0B4J1V9 F6XU50 Q0VGL2 Q76H82 Q9NRZ9
PDB IDs		3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91
Enriched GO Terms of Interacting Partners?
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