CASQ2 and CSNK2A2

Data Source:
HPRD (in vivo, in vitro)

		CASQ2	CSNK2A2
Description		calsequestrin 2	casein kinase 2 alpha 2
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GO Annotations	Cellular Component	Cytoplasm Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Calcium-dependent Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Heart Rate Detection Of Calcium Ion Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Sequestering Of Calcium Ion Protein Polymerization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cardiac Muscle Contraction Regulation Of Membrane Repolarization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Cardiac Conduction	Protein Folding Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Stimuli-sensing channels Ion homeostasis	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases		Catecholaminergic polymorphic ventricular tachycardia
GWAS		Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 30578418) QRS duration ( 27577874 30012220 27659466)	Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		5 interacting genes: ANKRD1 CSNK2A1 CSNK2A2 FBXO7 TRDN	102 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		845	1459
HPRD ID		00256	00279
Ensembl ID		ENSG00000118729	ENSG00000070770
Uniprot IDs		O14958	P19784
PDB IDs		2VAF 6OWV 6OWW	3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU
Enriched GO Terms of Interacting Partners?
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