MEGF10 and AARS2

Data Source:
HPRD (two hybrid)

		MEGF10	AARS2
Description		multiple EGF like domains 10	alanyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Plasma Membrane Integral Component Of Membrane Cell Projection	Mitochondrion
	Molecular Function	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding	TRNA Binding Aminoacyl-tRNA Editing Activity Alanine-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Amino Acid Binding
	Biological Process	Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation	TRNA Modification Alanyl-tRNA Aminoacylation Mitochondrial Alanyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways			Mitochondrial tRNA aminoacylation
Drugs			Alanine
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral content ( 31790847) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311) Initial pursuit acceleration ( 29064472) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		23 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1	3 interacting genes: EHHADH MEGF10 YWHAQ
Entrez ID		84466	57505
HPRD ID		14384	12397
Ensembl ID		ENSG00000145794	ENSG00000124608
Uniprot IDs		Q96KG7	Q5JTZ9
PDB IDs			6NLQ 6NLY 6NOW
Enriched GO Terms of Interacting Partners?
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