LZTS2 and ZNF446

Data Source:
BioGRID (two hybrid)

		LZTS2	ZNF446
Description		leucine zipper tumor suppressor 2	zinc finger protein 446
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Plasma Membrane Midbody Vesicle	Chromatin Extracellular Space Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Obesity-related traits ( 23251661) Uric acid clearance ( 28095793)
Interacting Genes		217 interacting genes: ABI2 ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C1orf109 C2CD6 C8orf33 CABP5 CARD9 CATSPER1 CBX8 CCDC187 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CDKN1A CEP57L1 CFAP206 CHCHD3 CHIC2 CLIP4 CNNM3 COPB1 CSNK1D CWF19L2 DCUN1D1 DGCR6 DGCR6L DUSP4 DYRK2 EHHADH EIF3D EIF4E2 EXOSC5 FAM107A FAM124B FAM161A FAM214B FAM221B FAM50B FAM74A4 FAM90A1 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 GADD45GIP1 GATA1 GCC1 GEM GFI1B GIPC2 GLIDR GLYCTK GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IGFN1 INO80B IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 LMO3 MAB21L3 MAGEB4 MAPK1 MEMO1 MID2 MORF4L1 MORF4L2 MORN3 MOS MTA1 MYOZ1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PATZ1 PHF1 PHF19 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRR35 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3KBP1 SH3RF2 SHFL SLC15A3 SLC25A6 SLC39A14 SLU7 SMARCB1 SMARCD1 SMIM3 SNHG11 SNW1 SNX31 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 SYT17 TBC1D7 TCEA2 TEAD4 THAP10 THAP7 TLE5 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TSSK2 TSSK3 TTC23 TTLL10 TXNL4A UBASH3A UBASH3B USF2 USP2 UTP14C VEZF1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZC2HC1C ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF124 ZNF20 ZNF250 ZNF408 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581 ZNF648	60 interacting genes: ACTN2 ANKRD1 CCNK COPS2 CYSRT1 DGCR6 DGCR6L EHMT2 EVI5 FHL5 FRMD8 FRS3 GOLGA6L9 INCA1 KIFC3 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP3-1 LNX1 LZTS2 MAGOHB MDFI NBPF19 NOTCH2NLA PGBD1 PIN1 REL SCAND1 SIVA1 SUFU TAX1BP1 TRIM27 UBE2I UBE3A ZKSCAN4 ZKSCAN7 ZNF165 ZNF18 ZNF232 ZNF24 ZNF263 ZNF396 ZNF397 ZNF483 ZNF496 ZSCAN12 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN22 ZSCAN23 ZSCAN29 ZSCAN30 ZSCAN32 ZSCAN9
Entrez ID		84445	55663
HPRD ID		14341	07934
Ensembl ID		ENSG00000107816	ENSG00000083838
Uniprot IDs		B4DP66 Q9BRK4	Q8NDK2 Q9NWS9 Q9UFF2
PDB IDs
Enriched GO Terms of Interacting Partners?
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